Parental dietary fat intake alters offspring microbiome and immunity.

ABSTRACT: Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, in part, driven this immune dysregulation. However, dietary fatty acids also influence immunity, partially through modulation of responses to microbes. Prior reports have described the direct effects of high-fat diets on the gut microbiome and inflammation, and some have additionally shown metabolic consequences for offspring. Our study sought to expand on these previous observations to identify the effects of parental diet on offspring immunity using mouse models to provide insights into challenging aspects of human health. To test the hypothesis that parental dietary fat consumption during gestation and lactation infl

SUBMITTER: Myles IA 

PROVIDER: S-EPMC3831371 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature