Identification of three new Alu Yb subfamilies by source tracking of recently integrated Alu Yb elements.

ABSTRACT:

Background

Alu elements are the most abundant mobile elements in the human genome, with over 1 million copies and constituting more than 10% of the genome. The majority of these Alu elements were inserted into the primate genome 35 to 60 million years ago, but certain subfamilies of Alu elements are relatively very new and suspected to be still evolving. We attempted to trace the source/master copies of all human-specific members of the Alu Yb lineage using a computational approach by clustering similar Yb elements and constructing an evolutionary relation among the members of a cluster.

Results

We discovered that one copy of Yb8 at 10p14 is the source of several active Yb8 copies, which retrotransposed to generate 712 copies or 54% of all human-specific Yb8 elements. We det

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC3831846 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature