Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.

ABSTRACT:

Objectives

We have used genome-wide association studies to identify variants that are associated with vulnerability to develop heroin addiction.

Methods

DNA from 325 methadone stabilized, former severe heroin addicts and 250 control individuals were pooled by ethnicity (Caucasian and African-American) and analyzed using the Affymetrix GeneChip Mapping 100 K Set. Genome-wide association tests were conducted.

Results

The strongest association with vulnerability to develop heroin addiction, with experiment-wise significance (P=0.035), was found in Caucasians with the variant rs10494334, a variant in an unannotated region of the genome (1q23.3). In African Americans, the variant most significantly associated with the heroin addiction vulnerability was rs950302, found in t

SUBMITTER: Nielsen DA 

PROVIDER: S-EPMC3832188 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature