Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni.

ABSTRACT:

Background

Campylobacter jejuni causes acute disease characterized by severe diarrhea containing blood and leukocytes, fever, and abdominal cramping. Disease caused by C. jejuni is dependent on numerous bacterial and host factors. C. jejuni invasion of the intestinal epithelial cells is seen in both clinical samples and animal models indicating that host cell invasion is, in part, necessary for disease. C. jejuni utilizes a flagellar Type III Secretion System (T3SS) to deliver the Campylobacter invasion antigens (Cia) to host cells. The Cia proteins modulate host cell signaling leading to actin cytoskeleton rearrangement necessary for C. jejuni host cell invasion, and are required for the development of disease.

Results

This study was based on the hypothesis that the C. jeju

SUBMITTER: Samuelson DR 

PROVIDER: S-EPMC3832248 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature