Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow-up of up to 3 years.

ABSTRACT:

Background

Chronic obstructive pulmonary disease is a major inflammatory disease of the airways and an enormous therapeutic challenge. Within the spectrum of chronic obstructive pulmonary disease, pulmonary emphysema is characterized by the destruction of the alveolar walls with an increase in the air spaces distal to the terminal bronchioles but without significant pulmonary fibrosis. Therapeutic options are limited and palliative since they are unable to promote morphological and functional regeneration of the alveolar tissue. In this context, new therapeutic approaches, such as cell therapy with adult stem cells, are being evaluated.

Objective

This article aims to describe the follow-up of up to 3 years after the beginning of a phase I clinical trial and discuss the spiro

SUBMITTER: Stessuk T 

PROVIDER: S-EPMC3832317 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature