Zwitterionic polymer-modified silicon microring resonators for label-free biosensing in undiluted human plasma.

ABSTRACT: A widely acknowledged goal in personalized medicine is to radically reduce the costs of highly parallelized, small fluid volume, point-of-care and home-based diagnostics. Recently, there has been a surge of interest in using complementary metal-oxide-semiconductor (CMOS)-compatible silicon photonic circuits for biosensing, with the promise of producing chip-scale integrated devices containing thousands of orthogonal sensors, at minimal cost on a per-chip basis. A central challenge in biosensor translation is to engineer devices that are both sensitive and specific to a target analyte within unprocessed biological fluids. Despite advances in the sensitivity of silicon photonic biosensors, poor biological specificity at the sensor surface remains a significant factor limiting assay performan

SUBMITTER: Kirk JT 

PROVIDER: S-EPMC3832353 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature