Genotype by energy expenditure interaction with metabolic syndrome traits: the Portuguese healthy family study.

ABSTRACT: Moderate-to-high levels of physical activity are established as preventive factors in metabolic syndrome development. However, there is variability in the phenotypic expression of metabolic syndrome under distinct physical activity conditions. In the present study we applied a Genotype X Environment interaction method to examine the presence of GxEE interaction in the phenotypic expression of metabolic syndrome. A total of 958 subjects, from 294 families of The Portuguese Healthy Family study, were included in the analysis. Total daily energy expenditure was assessed using a 3 day physical activity diary. Six metabolic syndrome related traits, including waist circumference, systolic blood pressure, glucose, HDL cholesterol, total cholesterol and triglycerides, were measured and adjusted fo

SUBMITTER: Santos DM 

PROVIDER: S-EPMC3832360 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature