Association of A561C and G98T polymorphisms in E-selectin gene with coronary artery disease: a meta-analysis.

ABSTRACT:

Objective

E-selectin (SELE) mediates the rolling and adhesion of leukocytes on activated endothelial cells and plays a critial role in the pathogenesis of coronary artery disease (CAD). Associatons between the A561C and G98T polymorphisms of the SELE gene and CAD risk were investigated broadly, but the results were inconsistent. In the present study, we performed a meta-analysis to systematically evaluate the associations between the two polymorphisms and the risk of CAD.

Methods

Comprehensive research was conducted to identify relevant studies. The fixed or random effect model was selected based on the heterogeneity among studies, which was evaluated with Q-test and Ι(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Peters's line

SUBMITTER: Wang X 

PROVIDER: S-EPMC3832468 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature