Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation.

ABSTRACT: Neurons can have widely differing intrinsic membrane properties, in particular the density of specific conductances, but how these contribute to characteristic neuronal activity or pattern formation is not well understood. To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. We then examined the sensitivity of measures of output activity to conductances and how the model instances responded t

SUBMITTER: Lamb DG 

PROVIDER: S-EPMC3832487 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature