Epistatic genetic effects among Alzheimer's candidate genes.

ABSTRACT:

Background

Novel risk variants for late-onset Alzheimer's disease (AD) have been identified and replicated in genome-wide association studies. Recent work has begun to address the relationship between these risk variants and biomarkers of AD, though results have been mixed. The aim of the current study was to characterize single marker and epistatic genetic effects between the top candidate Single Nucleotide Polymorphisms (SNPs) in relation to amyloid deposition.

Methods

We used a combined dataset across ADNI-1 and ADNI-2, and looked within each dataset separately to validate identified genetic effects. Amyloid was quantified using data acquired by Positron Emission Tomography (PET) with (18)F-AV-45.

Results

Two SNP-SNP interactions reached significance when correctin

SUBMITTER: Hohman TJ 

PROVIDER: S-EPMC3832488 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature