Evolution of an avian H5N1 influenza A virus escape mutant.

ABSTRACT:

Aim

To investigate the genetic constitution of an escape mutant H5N1 strain and to screen the presence of possible amino acid signatures that could differentiate it from other Egyptian H5N1 strains.

Methods

Phylogenetic, evolutionary patterns and amino acid signatures of the genes of an escape mutant H5N1 influenza A virus isolated in Egypt on 2009 were analyzed using direct sequencing and multisequence alignments.

Results

All the genes of the escape mutant H5N1 strain showed a genetic pattern potentially related to Eurasian lineages. Evolution of phylogenetic trees of different viral genes revealed the absence of reassortment in the escape mutant strain while confirming close relatedness to other H5N1 Egyptian strains from human and avian species. A variety of amino

SUBMITTER: Hassanin KM 

PROVIDER: S-EPMC3832911 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature