MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours.

ABSTRACT:

Background

Hereditary breast cancer comprises 5-10% of all breast cancers. Mutations in two high-risk susceptibility genes, BRCA1 and BRCA2, along with rare intermediate-risk genes and common low-penetrance alleles identified, altogether explain no more than 45% of the high-risk breast cancer families, although the majority of cases are unaccounted for and are designated as BRCAX tumours. Micro RNAs have called great attention for classification of different cancer types and have been implicated in a range of important biological processes and are deregulated in cancer pathogenesis.

Methods

Here we have performed an exploratory hypothesis-generating study of miRNA expression profiles in a large series of 66 primary hereditary breast tumours by microarray analysis.

Results

SUBMITTER: Tanic M 

PROVIDER: S-EPMC3833208 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature