Nogo-A expression after focal ischemic stroke in the adult rat.

ABSTRACT:

Background and purpose

The Nogo-A protein is an important inhibitor of axonal remodeling after central nervous system injuries, including ischemic stroke. Interfering with the function of Nogo-A via infusion of a therapeutic anti-Nogo-A antibody after stroke increases neuronal remodeling and enhances functional recovery in rats. In this study, we describe the regional distribution of cortical neurons expressing Nogo-A in normal rats and following middle cerebral artery occlusion (MCAO).

Methods

Normal and post-MCAO neuronal Nogo-A expression were described via immunohistochemical analyses. All brains were processed for Nogo-A and parvalbumin expression. The level of Nogo-A expression was scored for each cortical area or white matter structure of interest. The number and fluo

SUBMITTER: Cheatwood JL 

PROVIDER: S-EPMC3833276 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature