The Campylobacter jejuni CiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease.

ABSTRACT:

Background

Enteric pathogens utilize a distinct set of proteins to modulate host cell signaling events that promote host cell invasion, induction of the inflammatory response, and intracellular survival. Human infection with Campylobacter jejuni, the causative agent of campylobacteriosis, is characterized by diarrhea containing blood and leukocytes. The clinical presentation of acute disease, which is consistent with cellular invasion, requires the delivery of the Campylobacter invasion antigens (Cia) to the cytosol of host cells via a flagellar Type III Secretion System (T3SS). We identified a novel T3SS effector protein, which we termed CiaD that is exported from the C. jejuni flagellum and delivered to the cytosol of host cells.

Results

We show that the host cell kinases

SUBMITTER: Samuelson DR 

PROVIDER: S-EPMC3833307 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature