The neuroinflammatory response in humans after traumatic brain injury.

ABSTRACT:

Aims

Traumatic brain injury is a significant cause of morbidity and mortality worldwide. An epidemiological association between head injury and long-term cognitive decline has been described for many years and recent clinical studies have highlighted functional impairment within 12 months of a mild head injury. In addition chronic traumatic encephalopathy is a recently described condition in cases of repetitive head injury. There are shared mechanisms between traumatic brain injury and Alzheimer's disease, and it has been hypothesized that neuroinflammation, in the form of microglial activation, may be a mechanism underlying chronic neurodegenerative processes after traumatic brain injury.

Methods

This study assessed the microglial reaction after head injury in a range of ag

SUBMITTER: Smith C 

PROVIDER: S-EPMC3833642 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature