Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study.

ABSTRACT: Perinatal mood disorders, such as postpartum depression (PPD), are costly for society, with potentially serious consequences for mother and child. While multiple genes appear to play a role in PPD susceptibility, the contributions of specific genetic variations remain unclear. Previously implicated as a candidate gene, the estrogen receptor alpha gene (ESR1) is a key player in mediating hormonal differences during pregnancy and the postpartum period. This study addresses genetic factors in perinatal mood disorders, testing nine polymorphisms in ESR1. Two hundred fifty-seven postpartum women were screened for mood disorders, including 52 women with PPD and 32 without any symptoms of mood disorders. We detected a significant association for the upstream TA microsatellite repeat with Edinburg

SUBMITTER: Pinsonneault JK 

PROVIDER: S-EPMC3833886 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature