Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine.

ABSTRACT:

Background

Higher serum cystatin C level is associated with an increased risk of hip fracture in postmenopausal white women, but there is a paucity of data for men. Whether estimated glomerular filtration rate (eGFR) based on cystatin C (eGFRcys) is superior in predicting hip fracture risk to eGFR based on creatinine (eGFRcr) or the combination (eGFR(cr-cys)) also is uncertain.

Study design

Nested case-cohort.

Setting & participants

Participants enrolled in the Osteoporotic Fractures in Men (MrOS) Study (5,994 men aged ≥ 65 years from 6 US centers) including a random subcohort of 1,602 men and 168 men with incident hip fractures (51 of whom were in the subcohort).

Predictor

eGFR(cys), eGFR(cr), and eGFR(cr-cys) computed using the CKD-EPI (Chronic Kidney Disease

SUBMITTER: Ensrud KE 

PROVIDER: S-EPMC3833961 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature