Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar Rhabdomyosarcoma.

ABSTRACT:

Unlabelled

Since the advent of tyrosine kinase inhibitors as targeted therapies in cancer, several receptor tyrosine kinases (RTK) have been identified as operationally important for disease progression. Rhabdomyosarcoma (RMS) is a malignancy in need of new treatment options; therefore, better understanding of the heterogeneity of RTKs would advance this goal. Here, alveolar RMS (aRMS) tumor cells derived from a transgenic mouse model expressing two such RTKs, platelet-derived growth factor (PDGFR)α and insulin-like growth factor (IGF)-1R, were investigated by fluorescence-activated cell sorting (FACS). Sorted subpopulations that were positive or negative for PDGFRα and IGF-1R dynamically altered their cell surface RTK expression profiles as early as the first cell division. Intere

SUBMITTER: Aslam MI 

PROVIDER: S-EPMC3834004 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature