Gene expression analysis of so called asian dust extracts in human acute myeloid leukemia cells.

ABSTRACT: As the frequency and the intensity of so called Asian dust (AD) events have increased, public concerns about the adverse health effects has spiked sharply over the last two decades. Despite the recent reports on the correlation between AD events and the risk for cardiovascular and respiratory disease, the nature of the toxicity and the degree of the risk are yet largely unknown. In the present study, we investigated the effects of the dichloromethane extract of AD (AD-X) and that of urban dust (NAD-X) collected during a non-AD period on gene expression in HL-60 cells using Illumina Sentrix HumanRef-8 Expression BeadChips. Global changes in gene expression were analyzed after 24 h of incubation with 50 or 100 μg/ml AD-X and NAD-X. By one-way analysis of variance (p < 0.05) and Benjamini-Hoc

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC3834465 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature