Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet.

ABSTRACT: Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analyses revealed phospholipid qualitative changes. As a result, linoleic acid-containing phosphatidylcholine and sphingomyelin and docosahexanoic acid-containing phosphatidylcholine were characterized as chronic exercise training-induced lipids. On the contrary, arachidonic acid-containing phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositol were characterized as high-fat diet-induced lipids. In addition, minor sphingomyelin, which has long-chain fatty acids, w

SUBMITTER: Goto-Inoue N 

PROVIDER: S-EPMC3834553 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature