An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.

ABSTRACT: 19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.

SUBMITTER: Kitson RR 

PROVIDER: S-EPMC3835074 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature