Bone marrow-derived Kruppel-like factor 10 controls reendothelialization in response to arterial injury.

ABSTRACT:

Objective

The objective of this study was to investigate the role of Kruppel-like factor (KLF) 10, a zinc-finger transcription factor, in bone marrow (BM)-derived cell responses to arterial endothelial injury. Accumulating evidence indicates that BM-derived progenitors are recruited to sites of vascular injury and contribute to endothelial repair.

Approach and results

In response to carotid artery endothelial denudation, KLF10 mRNA expression was markedly increased in both BM and circulating lin(-) progenitor cells. To examine the specific role of KLF10 in arterial reendothelialization, we used 2 models of endothelial denudation (wire- and thermal-induced injury) of the carotid artery in wild-type (WT) and KLF10(-/-) mice. WT mice displayed higher areas of reendothelializati

SUBMITTER: Wara AK 

PROVIDER: S-EPMC3835145 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature