Association of the receptor for advanced glycation end products gene polymorphisms and circulating RAGE levels with diabetic retinopathy in the Chinese population.

ABSTRACT:

Objectives

This study investigated the association between polymorphisms in the receptor for advanced glycation end products (RAGE) gene and the susceptibility to diabetic retinopathy (DR) in a Chinese population and identified a correlation between serum-soluble RAGE (sRAGE) levels and DR risk.

Materials and methods

We enrolled 1040 patients with type 2 diabetes mellitus: 372 patients with DR and 668 without retinopathy (NDR). All polymorphisms were genotyped by time-of-flight mass spectrometry. Serum levels of sRAGE were assayed by enzyme-linked immunosorbent assays. The interaction of SNPs was analyzed by multifactor dimensionality reduction (MDR).

Results

The frequency of the SS genotype for the G82S polymorphism was 12.4% in the DR group and 6.6% in the NDR group

SUBMITTER: Yang L 

PROVIDER: S-EPMC3835200 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature