Donor age and factors related to endothelial cell loss 10 years after penetrating keratoplasty: Specular Microscopy Ancillary Study.

ABSTRACT:

Objective

To examine the effect of donor age and other perioperative factors on long-term endothelial cell loss after penetrating keratoplasty (PKP).

Design

Multicenter, prospective, double-masked clinical trial.

Participants

We included 176 participants from the Cornea Donor Study cohort who had not experienced graft failure ≥ 10 years after PKP for a moderate risk condition (principally Fuchs' dystrophy or pseudophakic/aphakic corneal edema).

Methods

Corneas from donors 12 to 75 years old were assigned to participants using a randomized approach, without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines. Images of the central endothelium were obtained preoperatively and at intervals for 10 ye

SUBMITTER: Writing Committee for the Cornea Donor Study Research Group 

PROVIDER: S-EPMC3835371 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature