Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma.

ABSTRACT:

Background

Tobacco and alcohol consumption are risk factors for head and neck squamous cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking increased TP53 and other mutations in HNSCC; however, the effects of alcohol consumption on these genetic alterations remain unknown. We explored the association between alcohol consumption and somatic copy-number alterations (SCNAs) across the whole genome in human papillomavirus (HPV)-negative HNSCCs, and compared with the effects of smoking on genetic alterations.

Methods

SCNA and TP53 mutations in tumor samples were examined by high-resolution comparative genomic hybridization microarray 180K and by direct sequencing, respectively, and statistically analyzed for associations with alcohol consumption and smo

SUBMITTER: Urashima M 

PROVIDER: S-EPMC3835411 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature