Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes.

ABSTRACT:

Objective

To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year.

Research design and methods

Sixty-eight individuals (mean age 13.3 ± 5.7 years; 35% female, 92% Caucasian) were randomized to HCLC followed by SAP therapy (intensive group; N = 48) or to the usual-care group treated with multiple daily injections or insulin pump therapy (N = 20). Primary outcome was C-peptide concentrations during mixed-meal tolerance tests at 12 months.

Results

Intensive-group participants initiated HCLC a median of 6 days after diagnosis for a median duration of 71.3 h, during which median participant mean g

SUBMITTER: Buckingham B 

PROVIDER: S-EPMC3836135 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature