Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.

ABSTRACT: Thymic stromal lymphopoietin (TSLP) recently has emerged as a key cytokine in the development of type 2 immune responses. Although traditionally associated with allergic inflammation, type 2 responses are also recognized to contribute to the pathogenesis of tissue fibrosis. However, the role of TSLP in the development of non-allergen-driven diseases, characterized by profibrotic type 2 immune phenotypes and excessive fibroblast activation, remains underexplored. Fibroblasts represent the key effector cells responsible for extracellular matrix production but additionally play important immunoregulatory roles, including choreographing immune cell recruitment through chemokine regulation. The aim of this study was to examine whether TSLP may be involved in the pathogenesis of a proto-typical

SUBMITTER: Datta A 

PROVIDER: S-EPMC3836180 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature