Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions.

ABSTRACT:

Background

Individuals with ulcerative colitis (UC) are at increased risk for colorectal cancer. The standard method of surveillance for neoplasia in UC by colonoscopy is invasive and can miss flat lesions. We sought to identify a gene expression signature in nondysplastic mucosa without active inflammation that could serve as a marker for remote neoplastic lesions.

Methods

Gene expression was analyzed by complementary DNA microarray in 5 normal controls, 4 UC patients without dysplasia, and 11 UC patients harboring remote neoplasia. Common gene ontology pathways of significantly differentially expressed genes were identified. Expression of genes which were progressively and significantly upregulated from controls to UC without neoplasia, to UC with remote neoplasia were eva

SUBMITTER: Pekow J 

PROVIDER: S-EPMC3836269 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature