Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.

ABSTRACT:

Background

It is widely accepted that chronic inflammation plays a role in the etiology of colorectal cancer. Using a two-stage design, we examined the associations between colorectal cancer and common variation in 37 key genes in the inflammation and innate immunity pathways.

Methods

In the discovery stage, 2,322 discordant sibships (2,535 cases, 3,915 sibling controls) from the Colorectal Cancer Family Registry were genotyped for more than 600 tagSNPs and 99 single-nucleotide polymorphisms (SNP) were selected for further examination based on strength of association. In the second stage, 351 SNPs tagging gene regions covered by the 99 SNPs were tested in 4,783 Multiethnic Cohort subjects (2,153 cases, 2,630 controls).

Results

The association between rs9858822 in the

SUBMITTER: Wang H 

PROVIDER: S-EPMC3836607 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature