Cell-based multi-parametric model of cleft progression during submandibular salivary gland branching morphogenesis.

ABSTRACT: Cleft formation during submandibular salivary gland branching morphogenesis is the critical step initiating the growth and development of the complex adult organ. Previous experimental studies indicated requirements for several epithelial cellular processes, such as proliferation, migration, cell-cell adhesion, cell-extracellular matrix (matrix) adhesion, and cellular contraction in cleft formation; however, the relative contribution of each of these processes is not fully understood since it is not possible to experimentally manipulate each factor independently. We present here a comprehensive analysis of several cellular parameters regulating cleft progression during branching morphogenesis in the epithelial tissue of an early embryonic salivary gland at a local scale using an on lattice

SUBMITTER: Ray S 

PROVIDER: S-EPMC3836695 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature