MicroRNA-gene association as a prognostic biomarker in cancer exposes disease mechanisms.

ABSTRACT: The transcriptional networks that regulate gene expression and modifications to this network are at the core of the cancer phenotype. MicroRNAs, a well-studied species of small non-coding RNA molecules, have been shown to have a central role in regulating gene expression as part of this transcriptional network. Further, microRNA deregulation is associated with cancer development and with tumor progression. Glioblastoma Multiform (GBM) is the most common, aggressive and malignant primary tumor of the brain and is associated with one of the worst 5-year survival rates among all human cancers. To study the transcriptional network and its modifications in GBM, we utilized gene expression, microRNA sequencing, whole genome sequencing and clinical data from hundreds of patients from different da

SUBMITTER: Ben-Hamo R 

PROVIDER: S-EPMC3836703 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature