Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: an Egyptian study.

ABSTRACT:

Aim

To assess co-stimulatory and co-inhibitory markers of dendritic cells (DCs) in hepatitis C virus (HCV) infected subjects with and without uremia.

Methods

Three subject groups were included in the study: group 1 involved 50 control subjects, group 2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing hemodialysis. CD83, CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by real-time polymerase chain reaction. Interleukin-10 (IL-10) and hyaluronic acid (HA) levels were also assessed. All findings were correlated with disease activity, viral load and fibrogenesis.

Results

There was a significant decrease in co-stimulatory markers; CD83, CD86

SUBMITTER: Fouad H 

PROVIDER: S-EPMC3837270 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature