Ontology highlight
ABSTRACT:
SUBMITTER: Dejnirattisai W
PROVIDER: S-EPMC3837288 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100501 5979
Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibody-dependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are hi ...[more]