Iron Oxide-labeled Collagen Scaffolds for Non-invasive MR Imaging in Tissue Engineering.

ABSTRACT: Non-invasive imaging holds significant potential for implementation in tissue engineering. It can e.g. be used to monitor the localization and function of tissue-engineered implants, as well as their resorption and remodelling. Thus far, however, the vast majority of efforts in this area of research have focused on the use of ultrasmall super-paramagnetic iron oxide (USPIO) nanoparticle-labeled cells, colonizing the scaffolds, to indirectly image the implant material. Reasoning that directly labeling scaffold materials might be more beneficial (enabling imaging also in case of non-cellularized implants), more informative (enabling the non-invasive visualization and quantification of scaffold degradation) and more easy to translate into the clinic (since cell-free materials are less complex

SUBMITTER: Mertens ME 

PROVIDER: S-EPMC3837415 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature