Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?

ABSTRACT: EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC3837553 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature