The nature of anterograde and retrograde memory impairment after damage to the medial temporal lobe.

ABSTRACT: The study of anterograde and retrograde amnesia (AA and RA) in the laboratory and the clinic has provided important information about the structure and organization of memory. The severity of AA is usually correlated with the severity of RA. Nevertheless, variations in the expression of AA and RA have been reported, which presumably reflect variation in the locus and extent of brain damage. The relationship between AA and RA has rarely been described quantitatively in groups of patients where detailed anatomical information is available. We have quantified the severity of AA and RA for factual information in 11 memory-impaired patients with bilateral medial temporal lobe lesions, including 5 for whom detailed post-mortem neurohistological information was available. The findings describe an

SUBMITTER: Smith CN 

PROVIDER: S-EPMC3837701 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature