Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture.

ABSTRACT: Hydrogels have numerous biomedical applications including synthetic matrices for cell culture and tissue engineering. Here we report the development of hydrogel based multifunctional matrices that not only provide three-dimensional structural support to the embedded cells but also can simultaneously provide potentially beneficial dynamic mechanical and electrical cues to the cells. A unique aspect of these matrices is that they undergo reversible, anisotropic bending dynamics in an electric field. The direction and magnitude of this bending can be tuned through the hydrogel crosslink density while maintaining the same electric potential gradient, allowing control over the mechanical strain imparted to the cells in a three-dimensional environment. The conceptual design of these hydrogels wa

SUBMITTER: Lim HL 

PROVIDER: S-EPMC3837709 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature