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SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production.

ABSTRACT: The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production.

SUBMITTER: Ulanova D 

PROVIDER: S-EPMC3837817 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production.

Ulanova Dana D   Kitani Shigeru S   Fukusaki Eiichiro E   Nihira Takuya T  

Applied and environmental microbiology 20131011 24

The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production. ...[more]

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