Periodontal treatment downregulates protease-activated receptor 2 in human gingival crevicular fluid cells.

ABSTRACT: Protease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced by Porphyromonas gingivalis and by neutrophil protease 3 (P3). PAR2 activation plays a relevant role in inflammatory processes by inducing the release of important inflammatory mediators associated with periodontal breakdown. The effects of periodontal treatment on PAR2 expression and its association with levels of proinflammatory mediators and activating proteases were investigated in chronic periodontitis patients. Positive staining for PAR2 was observed in gingival crevicular fluid cells and was reflective of tissue destruction. Overexpression of PAR2 was positively associated with inflammatory clinical parameters

SUBMITTER: Euzebio Alves VT 

PROVIDER: S-EPMC3837994 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature