CpG dinucleotide frequencies reveal the role of host methylation capabilities in parvovirus evolution.

ABSTRACT: Parvoviruses are rapidly evolving viruses that infect a wide range of hosts, including vertebrates and invertebrates. Extensive methylation of the parvovirus genome has been recently demonstrated. A global pattern of methylation of CpG dinucleotides is seen in vertebrate genomes, compared to "fractional" methylation patterns in invertebrate genomes. It remains unknown if the loss of CpG dinucleotides occurs in all viruses of a given DNA virus family that infect host species spanning across vertebrates and invertebrates. We investigated the link between the extent of CpG dinucleotide depletion among autonomous parvoviruses and the evolutionary lineage of the infected host. We demonstrate major differences in the relative abundance of CpG dinucleotides among autonomous parvoviruses which sha

SUBMITTER: Upadhyay M 

PROVIDER: S-EPMC3838256 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature