Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability.

ABSTRACT:

Background

Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of neural circuitry in schizophrenia. However, the structural integrity of the superficial WM, comprising short-range association (U-fibers) and intracortical axons, has not been investigated in schizophrenia.

Methods

High-resolution structural and diffusion tensor images and sophisticated cortical pattern matching methods were used to measure and compare global and local variations in superficial WM fractional anisotropy between schizophrenia patients and their relatives and community comparison subjects and their relatives (n = 150).

Results

Compared with control subjects, patients showed reduced superficial WM fractional anisotropy distribut

SUBMITTER: Phillips OR 

PROVIDER: S-EPMC3838300 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature