Congenital microcephaly with a simplified gyral pattern: associated findings and their significance.

ABSTRACT:

Background and purpose

Primary microcephaly is an incompletely understood malformation that is often associated with developmental brain anomalies, yet whether the associated anomalies result from the microcephaly itself or from associated developmental/genetic mishaps is not yet understood. This study reviewed and analyzed a large number of MR imaging scans of children with microcephaly to determine the frequency of associated morphologic findings and to assess whether these findings were associated with the severity of the microcephaly.

Materials and methods

MR images of 119 patients with clinically diagnosed microcephaly were retrospectively reviewed, focusing on the degree of microcephaly, simplification of gyri, white matter volume, abnormalities of the corpus callosum,

SUBMITTER: Adachi Y 

PROVIDER: S-EPMC3838394 | biostudies-literature | 2011 Jun-Jul

REPOSITORIES: biostudies-literature