Novel interactions of the TRTK12 peptide with S100 protein family members: specificity and thermodynamic characterization.

ABSTRACT: The S100 protein family consists of small, dimeric proteins that exert their biological functions in response to changing calcium concentrations. S100B is the best-studied member and has been shown to interact with more than 20 binding partners in a calcium-dependent manner. The TRTK12 peptide, derived from the consensus binding sequence for S100B, has previously been found to interact with S100A1 and has been proposed to be a general binding partner of the S100 family. To test this hypothesis and gain a better understanding of the specificity of binding for the S100 proteins, 16 members of the human S100 family were screened against this peptide and its alanine variants. Novel interactions were found with only two family members, S100P and S100A2, indicating that TRTK12 selectively intera

SUBMITTER: Wafer LN 

PROVIDER: S-EPMC3839042 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature