Copper-Catalyzed Carboxylation of Aryl Iodides with Carbon Dioxide.

ABSTRACT: A method for carboxylation of aryl iodides with carbon dioxide has been developed. The reaction employs low loadings of copper iodide/TMEDA or DMEDA catalyst, 1 atm of CO2, DMSO or DMA solvent, and proceeds at 25-70 °C. Good functional group tolerance is observed, with ester, bromide, chloride, fluoride, ether, hydroxy, amino, and ketone functionalities tolerated. Additionally, hindered aryl iodides such as iodomesitylene can also be carboxylated.

SUBMITTER: Tran-Vu H 

PROVIDER: S-EPMC3839347 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature