Central role of RET in thyroid cancer.

ABSTRACT: RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.

SUBMITTER: Santoro M 

PROVIDER: S-EPMC3839608 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature