Insulin therapy and risk of prostate cancer: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Previous observational studies have shown that insulin therapy may modify the risk of prostate cancer (PCa). However, these studies yielded controversial results. Thus, we performed this meta-analysis to determine whether insulin use was associated with PCa risk in patients with diabetes mellitus (DM).

Method

A literature search was carried out in PubMed, EMBASE, and Cochrane Library Central database between January 1966 and January 2013. Fixed-effect and random-effect models were used to estimate pooled relative risks (RR) and corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analyses were also performed.

Result

A total of 11 (10 cohorts, and one case-control) studies published between 2007 and 2013 were included in the meta-a

SUBMITTER: Chen YB 

PROVIDER: S-EPMC3839878 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature