The impact of motor axon misdirection and attrition on behavioral deficit following experimental nerve injuries.

ABSTRACT: Peripheral nerve transection and neuroma-in-continuity injuries are associated with permanent functional deficits, often despite successful end-organ reinnervation. Axonal misdirection with non-specific reinnervation, frustrated regeneration and axonal attrition are believed to be among the anatomical substrates that underlie the poor functional recovery associated with these devastating injuries. Yet, functional deficits associated with axonal misdirection in experimental neuroma-in-continuity injuries have not yet been studied. We hypothesized that experimental neuroma-in-continuity injuries would result in motor axon misdirection and attrition with proportional persistent functional deficits. The femoral nerve misdirection model was exploited to assess major motor pathway misdirection a

SUBMITTER: Alant JD 

PROVIDER: S-EPMC3839879 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature