Identification of candidate serum proteins for classifying well-differentiated small intestinal neuroendocrine tumors.

ABSTRACT:

Background

Patients with well-differentiated small intestine neuroendocrine tumors (WD-SI-NETs) are most often diagnosed at a metastatic stage of disease, which reduces possibilities for a curative treatment. Thus new approaches for earlier detection and improved monitoring of the disease are required.

Materials and methods

Suspension bead arrays targeting 124 unique proteins with antibodies from the Human Protein Atlas were used to profile biotinylated serum samples. Discoveries from a cohort of 77 individuals were followed up in a cohort of 132 individuals both including healthy controls as well as patients with untreated primary WD-SI-NETs, lymph node metastases and liver metastases.

Results

A set of 20 antibodies suggested promising proteins for further verificati

SUBMITTER: Darmanis S 

PROVIDER: S-EPMC3839889 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature