The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression.

ABSTRACT:

Background

The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium.

Objective

Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles.

Methods

This cross-sectional study included 18 subjects (6 allergic asthma and allergic rhinitis; 6 allergic rhinitis; 6 healthy controls). The estimated false dis

SUBMITTER: Wagener AH 

PROVIDER: S-EPMC3839950 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature