Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration.

ABSTRACT:

Background

Alzheimer's disease (AD) is a debilitating age related progressive neurodegenerative disorder characterized by the loss of cognition, and eventual death of the affected individual. One of the major causes of AD is the accumulation of Amyloid-beta 42 (Aβ42) polypeptides formed by the improper cleavage of amyloid precursor protein (APP) in the brain. These plaques disrupt normal cellular processes through oxidative stress and aberrant signaling resulting in the loss of synaptic activity and death of the neurons. However, the detailed genetic mechanism(s) responsible for this neurodegeneration still remain elusive.

Methodology/ principle findings

We have generated a transgenic Drosophila eye model where high levels of human Aβ42 is misexpressed in the differentiating

SUBMITTER: Moran MT 

PROVIDER: S-EPMC3840013 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature